产品货号：
Z18966
中文名称：
IRE1/ERN1抗体
英文名称：
Anti-IRE1/ERN1 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-IRE1/ERN1 Antibody |
| 指标别名 | ERN1;hIRE1p;Inositol requiring protein 1;IRE1;Ire1 alpha;IRE1;ERN1;IRE1P;IRE1α |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | ELISA,WB,ICC,IF,IHC |
| 基因名称 | ERN1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | Anti-IRE1p antibody was raised against a peptide corresponding to 16 amino acids near the carboxy terminus of human IRE1P.The immunogen is located within the last 50 amino acids of IRE1p. |
| 计算分子量 | 110kDa |
| 成分 | IRE1p Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | IRE1p Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | Accumulation of malfolded proteins in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) and the upregulation of the ER molecular chaperones GRP78 and GRP 94.These proteins are normally bound to ER transmembrane proteins such as IRE1p and ATF6 but ER stress causes their dissociation.This allows IRE1p,a serine-threonine protein kinase to transduce the unfolded protein signal from the ER to the nucleus.IRE1p also has an endoribonuclease activity that is required to splice X-box binding protein (XBP1) mRNA converting it to a potent UPR transcriptional activation.Depletion of IRE1p through the expression of a dominant negative form of IRE1p has no effect on transfected cells,but cell death via apoptosis occurs under stress conditions that cause unfolded proteins to accumulate in the ER.Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Uniprot ID | O75460 |
| 基因名全称 | Endoplasmic reticulum to nucleus signaling 1 |
| 蛋白名全称 | Endoplasmic reticulum to nucleus signaling 1 |
| 推荐稀释比 | WB:0.5～2μg/mL;ICC:1μg/mL;IF:2～20μg/mL;IHC:2μg/mL.Antibody validated:Western Blot in human,mouse and rat samples;Immunocytochemistry in mouse samples;Immunofluorescence in human,mouse and rat samples;Immunohistochemistry in human and rat samples.All other applications and species not yet tested. |
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